Salivary interleukin-6, interleukin-8, and Tumor Necrosis Factor-alpha as a potential biomarker panel for early detection of oral squamous cell carcinoma

Abstract

Aim: Salivary components are now receiving more attention as potential biomarkers for various diseases. This study aims to investigate the possibility of using IL -6, IL -8 and TNF-α as salivary biomarkers for early detection of OSCC Methods: This study followed the PRISMA protocol for reviews and meta-analyses and used PubMed as a database to identify articles that examined salivary concentrations of these mediators as potential biomarkers for early detection of oral squamous cell carcinoma. Results: We found 14 studies that examined salivary markers in oral pathology and met the requirements for review. Conclusion: Most studies showed increased concentrations of these mediators in the saliva of patients with OSCC. However, the values of salivary concentrations of IL -6, IL -8, and TNF-α in both OSCC and healthy patients remain controversial. Moreover, salivary concentrations of these mediators are influenced by the presence of oral comorbidities or the use of mouthwashes.