Obtaining the bicomponent tissue adhesive from blood collected preoperatively

Abstract

The difference between primary and secondary hemostasis is that primary hemostasis is defined by the formation of the primary platelet plug whereas secondary hemostasis (coagulation) is defined by the formation of insoluble, cross-linked fibrin. Activated platelets are responsible for primary hemostasis and activated clotting factors are responsible for secondary hemostasis. Platelets play a crucial role in hemostasis and wound healing, with platelet-derived growth factors as a source of healing cytokines. Platelet concentrates for surgical use are innovative tools of regenerative medicine and have also been tested in oral and maxillofacial surgery. These products are extracts of the blood tissue, they are tissues themselves, and not pharmaceutical preparations. Fibrin tissue adhesive has applications in several fields of medicine, can be prepared by various methods.