A detailed study on the antitumor effects of consecrated drugs - digoxin and labetalol

Abstract

Cardiotonic glycosides and beta-blockers are drug classes intensely known for their benefits in cardiovascular diseases, having therapeutic utility in certain conditions and in pregnant women. Due to their established actions, in recent years attention has been directed towards the antitumor effect of cardiotonic glycosides and non-selective beta-blockers. Thus, the aim of the present study was to highlight the anticancer activity of digoxin and labetalol, both in vitro and in vivo, to continue evaluating their effects and to study in more detail their mechanisms of antitumor action. Analyzing the data, it can be say that digoxin, but also non-selective beta-blockers, including labetalol, are promising anticancer agents.