Mechanisms Of Oxidative Stress and Maternal-Fetal Involvement

Abstract

Oxidative stress is manifested at the maternal-fetal interface from the beginning of pregnancy. It plays a role both in the normal development of the placenta and in the pathophysiology of complications: miscarriage, preeclampsia, intrauterine growth restriction (IUGR) and premature rupture of membranes. We studied from an immunohistochemical point of view nine placentas from pregnant women between the ages of 35 and 40 who had miscarriages in the absence of an obvious medical cause with a control group consisting of 9 normal, up to term placentas. We studied the anti-Gluthatione antibody and METH1 patterns of staining. The results showed an obvious association of low values of GLUTH and METH1 with miscarriages.