Preparation and characterization of ear drop solutions based on herbal extracts

Abstract

Otitis is an infection in the ear caused by bacteria that causes pain and discomfort. If not treated in time, long-term complications can occur. An ear infection affects the middle ear; they are more common in children. Unlike the synthetic drugs, the herbal products have a complex composition, being complex mixtures of bioactive compounds. Aim and objectives: The main aims of this research were to develop a novel ear drop solution based on different phytocompounds and to characterize it by specific methods. Material and Methods: Mixed solutions based on Aloe vera and Tea tree extracts have been obtained and they have been characterized by pH measurements, UV-Vis spectroscopy, in vitro cytotoxicity and efficacy evaluations. Results and Conclusion: The present results indicate the obtaining of an ear drop solution that can be used in further clinical trials.