HPV implications in oral cancer carcinogenesis: a systematic review

Abstract

The topic itself is unknown to the majority of the population and HPV is not yet correlated by non medical people as an infection that can lead to oral carcinogenesis. HPV infection has no borders, in every population over the globe people are infected with at least one subtype of the human papilloma virus even unbeknownst to them. There is extensive research of how subtypes of the human papilloma virus infect the genital area, and especially the female genitalia, due to the fact that it is the main cause of cervical carcinogenesis. The following review of research articles related to the effects of HPV infection on carcinogenesis of the oral squamous cell carcinomas. Research articles were obtained from the database of National Library of Medicine of the United States of America, known as PubMed and the online database Google Scholar, relating to the age and sex of the patient, the site on which oral squamous cell carcinoma developed and the detection method. This systematic review aims to provide a comprehensive analysis of the existing literature regarding HPV-related OSCC, synthesising current knowledge and identifying key research gaps. Further research is needed on the field of cellular and molecular mechanism of infection, prevention, other factors that might influence HPV related carcinogenesis, early detection of biomarkers treatment methods and strategies, long term outcomes of patients treated of oral squamous cell carcinoma and patient that are infected of the subtypes sixteen and eighteen and finally its epidemiological character as an independent type of cancer.